Multiplexing And Multiple Access : Digital Communications Difference between Multiplexing and Multiple Access: Sr.No. Multiplexing Multiple Access 1 “In telecommunications and computer networks, multiplexing is a process where multiple analog message signals or digital data streams are combined into one signal over a shared medium.” “In telecommunications and computer networks, a channel access method or multiple access method allows several terminals connected to the same multipoint physical medium to transmit over it and to share its capacity.” 2 The multiplexed signal is transmitted over a communication channel, which may be a physical transmission medium. A channel-access scheme is based on a multiplex method that allows several data streams or signals to share the same communication channel or physical media.